[变异毒株]2021年12月15日,Omicron最新情况汇总
Tulio老师:
So one thing that we know from the Omicron is that tend to generate very high viral loads.
What it means, it means that the infection; and because the very transmissible variant tend to have higher level of virus replication; and one thing that we knew from children and from their other variants that one of the reasons why they didn't develop disease is the lower level of the virus.
So what we have seen the beginning, is large number of young children being hospitalized.
关于Omicron,我们已经知道的一个情况是,它往往会产生非常高的病毒载量。
(更高的病毒载量)意味着(更容易)感染。
因为传染性更高的变异株,往往具有更高的病毒复制水平。
我们从儿童以及其他变异株总结了一些经验,
(之前)儿童发病较少的原因之一在于病毒载量较低。
所以我们才在(Omicron疫情)一开始,就看到大量儿童需要住院。
防感染有效性从80%(vs Delta)下降到33%(vs Omicron);
防入院有效性从93%(vs Delta)下降到70%(vs Omicron);
Omicron导致重症的风险比第一波(B.1)下降29%;
儿童入院风险比第一波上升20%。
简单解读两句吧。
首先,之前咱简单提到过,
要品鉴疫苗的作用,
需要先自行在脑内把VE(保护效力)翻译为RR(相对风险),
Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift
Elisabetta Cameroni, Christian Saliba, John E. Bowen, Laura E. Rosen, Katja Culap, Dora Pinto, Anna De Marco, Samantha K. Zepeda, Julia di Iulio, Fabrizia Zatta, Hanna Kaiser, Julia Noack, Nisar Farhat, Nadine Czudnochowski, Colin Havenar-Daughton, Kaitlin R. Sprouse, Josh R. Dillen, Abigail E. Powell, Alex Chen, Cyrus Maher, Li Yin, David Sun, Leah Soriaga, Claes Gustafsson, Helen Chu, Nicholas M. Franko, Jenni Logue, Najeeha Talat Iqbal, Ignacio Mazzitelli, Jorge Geffner, Renata Grifantini, Andrea Gori, Agostino Riva, Olivier Giannini, Alessandro Ceschi, Paolo Ferrari, Alessandra Franzetti-Pellanda, Christian Garzoni, Christy Hebner, Lisa Purcell, Luca Piccoli, Matteo Samuele Pizzuto, Alexandra C Walls, Amalio Telenti, Herbert W Virgin, Antonio Lanzavecchia, David Veesler, Gyorgy Snell, Davide Corti
bioRxiv 2021.12.12.472269; doi: https://doi.org/10.1101/2021.12.12.472269