癌症相关数据库专题-CCLE

本周我们将介绍几个癌症相关的数据库，今天介绍的是CCLE（Cancer Cell Line Encyclopedia），它是Board Institute维护的一个癌症细胞系的数据库，目前有1,400多个cell line。

数据库简介

网站链接:https://portals.broadinstitute.org/ccle_legacy/home

导航栏的ANALYSIS TOOLS，可以选择如下工具进行分析（登录后才能使用该网站的完整功能）

• Integrative Genomics Viewer (IGV)
  A high performance integrated visualization of copy number, gene expression, phenotype and other genomic data.

• GENE-E
  A high performance visualization and analysis tool for RNAi and gene expression data.

• Differential Expression
  Heat map visualization and tabular results showing the differentially expressed genes.

• Gene Neighbors
  Heat map visualization showing gene expression values for co-expressed genes.

• Gene Set Enrichment Analysis (GSEA)
  A report showing pathway gene sets correlated with phenotype classes of interest.

推荐阅读

1.一些关于CCLE数据库的文章：
http://cancerres.aacrjournals.org/content/73/8_Supplement/2409.short
http://cancerres.aacrjournals.org/content/74/22/6390.short
https://clincancerres.aacrjournals.org/content/19/19_Supplement/IA2.abstract
http://onlinelibrary.wiley.com/doi/10.1002/cncy.21471/pdf 介绍了几个类似的数据库资源
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088557 讲解了high/low的知识
http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=7060697 药物相关
Anticancer drug sensitivity analysis: An integrated approach applied to Erlotinib sensitivity prediction in the CCLE database

2.生信菜鸟团博客相关资源
在我们生信菜鸟团博客(http://www.bio-info-trainee.com/)搜索CCLE，还有更多知识等着你:

• 对CCLE数据库可以做的分析
  http://www.bio-info-trainee.com/1327.html

• CCLE数据库几个知识点
  http://www.bio-info-trainee.com/1324.html